SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF MIXED VITAMINS - METAL COMPLEXES

ABSTRACT 

Some vitamin complexes and mixed ligand metal complexes were derived from Thiamine HCl, Ascorbic acid and Nicotinamide. The complexes were characterized by melting point, thin layer chromatograghy, conductivity measurement, infrared, uv/visible, nuclear magnetic resonance (1 Hnmr and 13 The results of the spectroscopic studies reveal that both Thiamine HCl and Nicotinamide act as monodentate ligands, coordinating through nitrogen of the pyrimidine ring (N-1 Cnmr) and atomic absorption spectroscopy. 1 Only Fe (III) and Mn (II) complexes of ascorbic acid form 6-coordinate geometry. ) position in Thiamine and that of pyridine ring in Nicotinamide. While Ascorbic acid acts as a bidentate ligand, coordinating through the oxygen of the carbonyl and that of enolic C-2 hydroxyl groups. Most of the complexes form 4-coordinate geometry. The antibacterial activity of the complexes and the ligands was carried out against Escherichia coli, Staphylococcus aureus and Bacillus subtilis. All the mixed ligand complexes show higher antibacterial activity compared with the vitamin-metal complexes. The antifungal activities of the complexes and the ligands were also carried out against Aspergillus flavus, Aspergillus niger and Penicillium species. All the mixed ligand metal complexes showed higher antifungal activity than the vitaminmetal complexes. The toxicological study was evaluated using albino rats. The results showed that there was no significant difference (P>0.05) in the Alkaline Phosphatase (ALP) activity of the tested organs and the control, hence the complexes are nontoxic.

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